Teratogenicity testing methods and protocols pdf

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teratogenicity testing methods and protocols pdf

Teratogenicity Testing - Methods and Protocols | Luís Félix | Springer

Stem cells in the body have a unique ability to renew themselves and give rise to more specialized cell types having functional commitments. Under specified growth conditions, these cell types remain unspecialized but can be triggered to become specific cell type of the body such as heart, nerve, or skin cells. This ability of embryonic stem cells for directed differentiation makes it a prominent candidate as a screening tool in revealing safer and better drugs. In addition, genetic variations and birth defects caused by mutations and teratogens affecting early human development could also be studied on this basis. Moreover, replacement of animal testing is needed because it involves ethical, legal, and cost issues. Thus, there is a strong requirement for validated and reliable, if achievable, human stem cell-based developmental assays for pharmacological and toxicological screening. Drugs can cause problems throughout pregnancy.
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Toxicological screening

It seems that you're in Germany. We have a dedicated site for Germany. This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Methods in Molecular Biology Free Preview.

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  1. Betsabé G. says:

    Toxicity testing of new compounds is essential for drug development process.

  2. Steffen B. says:

    Recommended for you

  3. Cesira E. says:

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  4. Eric C. says:

    Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal.

  5. Judgderpvajour says:

    Request PDF on ResearchGate | Teratogenicity Testing: Methods and Protocols | This detailed book provides a compilation of laboratory techniques and tests to.

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